Effects of β-Amyloid peptide on neurogenesis in brain hippocampus of mice and interfering effect of traditional Chinese medicine
- VernacularTitle:β-淀粉样肽对小鼠海马神经发生的影响及中药的干预作用
- Author:
Mengren ZHANG
;
Pingping ZUO
;
Xuekun LI
;
Lingna KONG
;
Saishan GUO
- Publication Type:Journal Article
- Keywords:
Amyloid peptide, neurogenesis, hippocampus, traditional Chinese medicine
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(7):390-392
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the changes of neurogenesis in the hippocampus of Alzheimer's model mice and the effect of traditional Chinese medicine Nao Fu Cong. MethodsAlzheimer's type dementia of mice was induced by Aβ25-35 icv.Space learning and memorial ability were tested with Morris Water Maze.The activity of NMDA and M receptor were measured with radio-ligand of MK-801 and QNB.Neurogenesis was observed with the BrdU immunohitochemistry.ResultsSpace learning and memorial ability significantly decreased(P<0.05),MK-801 binding increased and QNB binding decreased (P<0.001),BrdU positive cells decreased in hippocampus(P<0.05).After given drugs for 2 weeks,the mentioned changes were improved significantly(P<0.05,P<0.001,P<0.05).ConclusionsThe toxic effect of Aβ25-35 was involved with the inhibitory action of neurogenesis.Promoting the neurogenesis may be one of the mechanism of traditional Chinese medicine to treat the neurodegenerative diseases.
