The association between serum 25-hydroxyvitamin D and glycemic control in patients with diabetes mellitus
doi.org/10.15605/jafes.038.01.04
- Author:
Mariel Enverga
1
;
Maria Jocelyn Isidro
1
;
Nerissa Ang-Golangco
1
Author Information
1. Makati Medical Center, Makati City, Philippines
- Publication Type:Journal Article
- Keywords:
serum 25(OH)D
- MeSH:
Vitamin D;
diabetes mellitus;
glycemic control
- From:
Journal of the ASEAN Federation of Endocrine Societies
2023;38(1):13-20
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To determine the association between serum 25-hydroxyvitamin D (25(OH)D) and measures of glycemic control, hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG), in adult patients with diabetes mellitus.
Methodology:This is an analytical cross-sectional study of 270 patients with diabetes admitted to a tertiary hospital. Serum 25(OH)D levels were categorized as follows: sufficient (>30 ng/mL), insufficient (20 to 30 ng/mL), and deficient (<20 ng/mL). The correlation of HbA1c and FPG with serum 25(OH)D and other variables was determined using Spearman’s rho (ρ) coefficient. The risk factors associated with HbA1c ≥7% and FPG ≥126 mg/dL were determined using logistic regression analysis to generate crude and adjusted odds ratios. The null hypothesis was rejected at 0.05 α-level of significance.
Results:The median serum 25(OH)D was 18.92 (range 3.56–56.3) ng/mL. Ninety percent (245 patients) had vitamin D levels below 30 ng/mL. This study showed that vitamin D level is significantly but weakly correlated with patient’s age (ρ=0.339) and duration of diabetes (ρ=0.147), whereas it had inverse correlations with BMI (ρ=-0.134), HbA1c (ρ=-0.261), and FPG (ρ=-0.198).
Conclusion:In this study, we found a possible association between vitamin D levels and measures of glycemic control among this group of adult Filipino patients with diabetes mellitus, but further investigations in other cohorts of individuals with diabetes are needed.
- Full text:1919-Article Text-23109-1-10-20230516.pdf
