Detection of neutralizing antibodies among health care workers and staff fully-vaccinated against COVID-19 in a Baguio City tertiary hospital: A cross-sectional study
- Author:
Hope Cordoviz Warren-Baluyut, MD
1
;
Rhoda Lynn Orallo-Fajardo, MD
2
;
Karla Rhea Rillera-Posadas, MD
2
Author Information
- Publication Type:Journal Article
- MeSH: Neutralizing antibodies; COVID-19 vaccine; healthcare workers
- From: Philippine Journal of Internal Medicine 2023;61(2):65-71
- CountryPhilippines
- Language:English
-
Abstract:
Background:Coronavirus disease 2019, otherwise known as COVID-19 is caused by the novel coronavirus. The WHO
stated that as of April 24, 2020, no study has evaluated if the antibodies against COVID-19 confer immunity. The aim
therefore of this research is to determine the presence of neutralizing antibodies among fully vaccinated Health Care
workers and staff of Notre Dame de Chartres Hospital.
Methods:This study is a single-center, cross-sectional study conducted at Notre Dame de Chartres Hospital in Baguio City. This study was designed to determine the presence of neutralizing antibodies 6 months after the 2nd dose of COVID-19 vaccine, either with Sinovac (CoronaVac®), an inactivated virus, or Oxford AstraZeneca, a non-replicating viral vector. The study was approved by the Ethics Review Board of the Baguio General Hospital Medical Center. A total of 206 participants enrolled voluntarily in the study. Descriptive statistics such as frequency and percentage were used to determine the baseline characteristics of the research participants. The mean amounts of antibodies after vaccination against COVID-19 were determined. Independent-sample t-test was utilized to determine if there was a significant difference in antibody production when comparing the two brands of vaccine, according to sex, employee status, presence of at least one comorbidity, and history of COVID-19 vaccination. One-way analysis of variance (ANOVA) was used for the variable age. All statistical tests were conducted at p<0.05 level of significance. Computations were done using SPSS version 22.0.
Results:A total of 236 healthcare workers and staff of Notre Dame de Chartres Hospital were included in the study. Among the study participants given either Sinovac or AstraZeneca, 52.97% belong to the 20-30 years old age group. Most of them were females (69.92%). For employment status, healthcare workers comprised the majority of the study population at 71.61% while the rest (28.36%) were hospital staff. Most did not have any comorbidities, while 26.27% reported having comorbidities, with hypertension and asthma identified as the predominant diseases at 9.75% and 9.32%, respectively; followed by allergic rhinitis (5.32%) and diabetes mellitus (2.97%). Among the participants, 74.6% were never diagnosed with COVID-19, while 25.4% reported to have been infected, with 16.5% having only mild symptoms. Most of the study participants (67.4%) were inoculated with Sinovac® while the rest (32.6%) received AstraZeneca.
Conclusion:There was no significant difference in the mean amount of antibodies when grouped according to each of the following variables: age, sex, employee status, and comorbidities. These results apply to both SINOVAC and AstraZeneca groups. There was a significantly higher mean amount of antibodies in those who had previously contracted COVID-19 than in those who never had a previous infection. On the other hand, comparing the mean amount of antibodies between the two brands of vaccines, SinovacTM and AstraZenecaTM, those who were vaccinated with AstraZenecaTM developed higher amounts of antibodies than those who were vaccinated with SinovacTM. - Full text:PJIM 61.pdf
