High risk human papilloma virus (HPV) oropharyngeal squamous cell carcinoma in a private tertiary care setting in the Philippines: Prevalence, clinical characteristics and testing
doi.org/10.32412/pjohns.v38i1.2141
- Author:
Ann Margaret V. Chang, MD
1
;
Marissa Krizelda D. Santos, MD
1
;
William L. Lim, MD
1
Author Information
1. St. Lukes Medical Center
- Publication Type:Journal Article
- Keywords:
squamous cell carcinoma Abstract
- MeSH:
human papillomavirus;
oropharyngeal cancer;
p16
- From:
Philippine Journal of Otolaryngology Head and Neck Surgery
2023;38(1):28-34
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To determine the prevalence and describe the clinical characteristics of high risk HPV mong patients with oropharyngeal squamous cell carcinomas in our institution utilizing p16 and HPV DNA in-situ hybridization testing and to determine the factors associated with high risk HPV positivity.
Methods: Design: Retrospective Cohort Review
Setting: Tertiary Private Training Hospital
Participants: 29
Results:A total of 29 primary oropharyngeal squamous cell carcinomas were diagnosed during the 11-year study period (January 2010 to December 2021). Based on the HPV in-situ hybridization status, the prevalence of high risk HPV oropharyngeal squamous cell carcinoma in our institution was 52%. Majority of these cases were males (87.5%) with a median age of ≤55 years old (60%) who are non-smokers (88.2%) and non-drinkers of alcoholic beverages (80%). There was no statistically significant association between age group, sex, smoking status, alcohol intake, lymph node status and high risk HPV infection. The most common tumor site involved in HPV-positive oropharyngeal squamous cell carcinoma was the tonsil (87%). Majority demonstrated a nonkeratinizing histology (73%) with positive lymph node status (67%) upon clinical presentation. Fifteen (83%) of the 18 p16 positive squamous cell carcinomas were positive for high risk HPVDNA. Of note, 3 (17%) out of the 18 p16 positive squamous cell carcinomas turned out to have negative HPV DNA-ISH status.
Conclusion:Although no statistically significant correlation between any clinical characteristic with viral status was established, HPV-mediated oropharyngeal squamous cell carcinoma in this institution was commonly seen among males aged 54 years old and below who are nonsmokers and non-drinkers of alcoholic beverages with the palatine tonsil as the most common site presenting with a non-keratinizing histology. In terms of testing, p16 staining correlates well with high risk HPV status. Future studies utilizing a larger patient population may aid in elucidating statistically significant clinical associations in our local population
- Full text:ORIG ARTICLE (3).pdf
