Age Estimation Based on DNA Methylation and Its Application Prospects in Forensic Medicine.
10.12116/j.issn.1004-5619.2021.510604
- Author:
Zi-Wei WANG
1
;
Qian-Nan XU
1
;
Cheng-Tao LI
1
;
Xi-Ling LIU
1
Author Information
1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
- Publication Type:Journal Article
- Keywords:
DNA methylation;
age estimation;
epigenetics;
forensic genetics;
review
- MeSH:
DNA Methylation;
Forensic Genetics/methods*;
CpG Islands;
Forensic Medicine
- From:
Journal of Forensic Medicine
2023;39(1):72-82
- CountryChina
- Language:English
-
Abstract:
With the improvement of DNA methylation detection techniques, studies on age-related methylation sites have found more age-specific ones across tissues, which improves the sensitivity and accuracy of age estimation. In addition, the establishment of various statistical models also provides a new direction for the age estimation of tissues from different sources. This review summarizes the related studies of age estimation based on DNA methylation from the aspects of detection technology, age-related cytosine phosphate guanine site and model selection in recent years.
