Application and Prospect of RNA Profiling Analysis in Forensic Body Fluid Identification.
10.12116/j.issn.1004-5619.2021.510707
- Author:
Shou-Yu WANG
1
;
Rui-Yang TAO
2
;
Yi-Ping HOU
3
;
Cheng-Tao LI
2
Author Information
1. Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
2. Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
3. Institute of Forensic Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
body fluid;
capillary electrophoresis;
forensic genetics;
high-throughput sequencing;
real-time quantitative polymerase chain reaction (RT-qPCR);
review;
ribonucleic acid (RNA)
- MeSH:
Forensic Medicine/methods*;
Body Fluids/chemistry*;
RNA/analysis*;
Feces;
Forensic Genetics;
Semen/chemistry*;
Saliva/chemistry*
- From:
Journal of Forensic Medicine
2022;38(6):763-773
- CountryChina
- Language:English
-
Abstract:
In forensic physical evidence identification, the accurate identification of the individual origin and their body fluid composition of the biological samples obtained from the crime scene play a critical role in determining the nature of a crime. In recent years, RNA profiling has become one of the fastest developing methods for body fluids identification. Due to the characteristics of tissue or body fluid specific expression, various types of RNA markers have been proven to be promising candidate markers for body fluids identification in previous studies. This review summarizes the research progress of RNA markers in body fluids identification, including the RNA markers that have been effectively verified in current research and their advantages and disadvantages. Meanwhile, this review prospects the application of RNA markers in forensic medicine.
