Research Progress of DNA-Based Technologies for Postmortem Interval Estimation.
10.12116/j.issn.1004-5619.2022.420601
- Author:
Lan YANG
1
;
Xin WANG
2
;
Yong NIU
3
Author Information
1. School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, Shanxi Province, China.
2. Criminal Investigation Detachment of Huaibei Public Security Bureau, Huaibei 235000, Anhui Province, China.
3. Criminal Investigation Bureau of the Ministry of Public Security, Beijing 100006, China.
- Publication Type:Journal Article
- Keywords:
deoxyribonucleic acid (DNA);
flow cytometry (FCM);
forensic pathology;
image analysis;
postmortem interval;
real-time quantitative polymerase chain reaction (RT-qPCR);
review;
single cell gel electrophoresis
- MeSH:
Humans;
Postmortem Changes;
Autopsy/methods*;
DNA/genetics*;
Forensic Medicine;
Forensic Pathology
- From:
Journal of Forensic Medicine
2022;38(6):747-753
- CountryChina
- Language:English
-
Abstract:
In criminal investigations, postmortem interval (PMI) is important information to be inferred in homicide investigations, as well as the focus and the difficulty in forensic pathology research. Because the DNA content in different tissues is relatively constant and shows changes regularly with the extension of PMI, it has become a research hotspot of PMI estimation. This paper reviews the recent progress of PMI estimation technologies including DNA-based single cell gel electrophoresis, image analysis, flow cytometry, real-time fluorescence quantitative PCR and high-throughput sequencing, hoping to provide references for forensic medicine practice and scientific research.
