Genetic Polymorphism of 16 X-STR Loci in Xinjiang Uygur Population.
10.12116/j.issn.1004-5619.2021.511103
- Author:
Chun-Yan YUAN
1
;
Ruo-Cheng XIA
2
;
Su-Hua ZHANG
2
;
Li-Qin CHEN
1
;
Ya-Li WANG
1
;
Yi-Ling QU
2
;
Guang-Yuan YANG
1
;
Xin-Yu DONG
2
;
Si-Yu CHAI
2
;
Cheng-Tao LI
1
;
Rui-Yang TAO
2
Author Information
1. Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China.
2. Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
- Publication Type:Journal Article
- Keywords:
Uygur;
X chromosome;
Xinjiang;
forensic genetics;
genetic distance;
phylogenetic tree;
polymorphism, genetic;
short tandem repeat (STR)
- MeSH:
Female;
Humans;
Male;
DNA, Ribosomal;
Ethnicity/genetics*;
Gene Frequency;
Paternity;
Phylogeny;
Polymorphism, Genetic;
Microsatellite Repeats;
Chromosomes, Human, X/genetics*
- From:
Journal of Forensic Medicine
2022;38(4):500-506
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the genetic polymorphism and population genetic parameters of 16 X-STR loci in Xinjiang Uygur population.
METHODS:The Goldeneye® DNA identification system 17X was used to amplify 16 X-STR loci in 502 unrelated individuals (251 females and 251 males). The amplified products were detected by 3130xl genetic analyzer. Allele frequencies and population genetic parameters were analyzed statistically. The genetic distances between Uygur and other 8 populations were calculated. Multidimensional scaling and phylogenetic tree were constructed based on genetic distance.
RESULTS:In the 16 X-STR loci, a total of 67 alleles were detected in 502 Xinjiang Uygur unrelated individuals. The allele frequencies ranged from 0.001 3 to 0.572 4. PIC ranged from 0.568 8 to 0.855 3. The cumulative discrimination power in females and males were 0.999 999 999 999 999 and 0.999 999 999 743 071, respectively. The cumulative mean paternity exclusion chance in trios and in duos were 0.999 999 997 791 859 and 0.999 998 989 000 730, respectively. The genetic distance between Uygur population and Kazakh population was closer, and the genetic distance between Uygur and Han population was farther.
CONCLUSIONS:The 16 X-STR loci are highly polymorphic and suitable for identification in Uygur population, which can provide a powerful supplement for the study of individual identification, paternity identification and population genetics.
