Pathogenic Role of Autophagy in Rheumatic Diseases.
10.4078/jrd.2016.23.4.202
- Author:
Yun Jung CHOI
1
;
Wan Hee YOO
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. ywhim@jbnu.ac.kr
- Publication Type:Review
- Keywords:
Autophagy;
Immunity;
Rheumatic diseases;
Systemic lupus erythematosus;
Rheumatoid arthritis
- MeSH:
Adaptive Immunity;
Antigen Presentation;
Arthritis, Rheumatoid;
Autophagy*;
Cytoplasm;
Eukaryotic Cells;
Extracellular Traps;
Homeostasis;
Inflammasomes;
Lupus Erythematosus, Systemic;
Lysosomes;
Rheumatic Diseases*
- From:Journal of Rheumatic Diseases
2016;23(4):202-211
- CountryRepublic of Korea
- Language:English
-
Abstract:
Autophagy is a principle catabolic process mediated by lysosomes in eukaryotic cells. This is an intracellular homeostatic mechanism crucial for degradation in acidic lysosomal compartments of waste components from the cytoplasm. Autophagy research was initially focused on its degradation mechanism, but focus is now shifting to its effects on immunity. It contributes to detection and removal of pathogens as well as regulation of inflammasomes and neutrophil extracellular traps. Moreover, it is pivotal in antigen presentation and immune cell maturation, survival and homeostasis. The importance of autophagic pathways in normal and dysregulated immunity has become increasingly recognized in the past several years. Dysregulation of the autophagic pathway is implicated in the pathogenesis of several rheumatic diseases. In this review, we summarize the immunological function of autophagy in innate and adaptive immunity, and the functions of autophagy in the pathogenesis of rheumatic diseases.
