Research Status and Prospects of Non-Traumatic Fat Embolism in Forensic Medicine.
10.12116/j.issn.1004-5619.2020.401002
- Author:
Meng-Zhen ZHANG
1
;
Yun-le MENG
2
;
Hao-Sen LING
2
;
Shen HUANG
2
;
Qi MIAO
2
;
Yan-Lin ZHANG
2
;
Xing-An YANG
2
;
Dong-Ri LI
2
Author Information
1. The First Clinical Medical College, Southern Medical University, Guangzhou 510515, China.
2. School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.
- Publication Type:Review
- Keywords:
forensic pathology;
non-traumatic fat embolism;
pathophysiological mechanism;
review
- MeSH:
Autopsy;
Embolism, Fat/pathology*;
Forensic Medicine;
Forensic Pathology;
Humans;
Pulmonary Embolism/pathology*
- From:
Journal of Forensic Medicine
2022;38(2):263-266
- CountryChina
- Language:English
-
Abstract:
In the practice of forensic pathology, fat embolism is one of the common causes of death, which can be divided into two categories: traumatic and non-traumatic. Non-traumatic fat embolism refers to the blockage of small blood vessels by fat droplets in the circulatory blood flow caused by non-traumatic factors such as underlying diseases, stress, poisoning and lipid metabolism disorders. At present, it is believed that the production of non-traumatic fat embolism is related to the disturbance of lipid metabolism, C-reactive protein-related cascade reaction, the agglutination of chylomicron and very low-density lipoprotein. The forensic identification of the cause of death of non-traumatic fat embolism is mainly based on the case, systematic autopsy, HE staining and fat staining, but it is often missed or misdiagnosed by forensic examiners because of its unknown risk factors, hidden onset, the difficulty of HE staining observation and irregular implementation of fat staining. In view of the lack of attention to non-traumatic fat embolism in forensic identification, this paper reviews the concepts, pathophysiological mechanism, research progress, existing problems and countermeasures of non-traumatic fat embolism, providing reference for forensic scholars.
