Research Progress on the Omics of Methamphetamine Toxic Damage and Addiction.
10.12116/j.issn.1004-5619.2021.310201
- Author:
Cui ZHANG
1
;
Xu ZHAO
1
;
Hui-Jun WANG
1
;
Xia YUE
1
Author Information
1. School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.
- Publication Type:Journal Article
- Keywords:
addiction;
forensic toxicology;
genomics;
metabolomics;
methamphetamine;
proteomics;
review;
toxic effect;
transcriptomics
- MeSH:
Metabolome;
Metabolomics;
Methamphetamine/toxicity*;
Proteome;
Proteomics
- From:
Journal of Forensic Medicine
2021;37(6):776-787
- CountryChina
- Language:English
-
Abstract:
The mechanism of methamphetamine toxicity and addiction is the key research direction of forensic toxicology, and the development of omics technology provides a new platform for further study of this direction. METH toxic damage and addiction are reflected differently in genes, ribonucleic acid (RNA) transcription, protein and metabolism. This article summarizes the achievements and shortcomings of multi-omics technologies such as genome, transcriptome, metabolome and proteome in the study of METH damage and addiction, and discusses the strategies and advantages of multi-omics combined analysis in the study of METH toxic damage and addiction mechanism, in order to provide more useful reference information for forensic toxicology of METH.
