A Case of Primary Bone Marrow Diffuse Large B-cell Lymphoma Presenting with Polyarthritis.
10.4078/jrd.2016.23.4.256
- Author:
In Young KIM
1
;
Dam KIM
;
Byeong Bae PARK
;
Woong Soo LEE
;
Ji Young CHOI
;
Yoon Kyoung SUNG
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. sungyk@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Paraneoplastic syndromes;
Diffuse large-cell lymphoma;
Rheumatoid arthritis
- MeSH:
Antirheumatic Agents;
Arthritis*;
Arthritis, Rheumatoid;
B-Lymphocytes*;
Biopsy;
Bone Marrow*;
Diagnosis;
Drug Therapy;
Female;
Fever;
Foot;
Hand;
Humans;
Leukemia;
Lymphoma;
Lymphoma, B-Cell*;
Lymphoma, Large B-Cell, Diffuse;
Methotrexate;
Middle Aged;
Necrosis;
Paraneoplastic Syndromes;
Prednisolone
- From:Journal of Rheumatic Diseases
2016;23(4):256-260
- CountryRepublic of Korea
- Language:English
-
Abstract:
Polyarthritis is a common manifestation of rheumatologic disorders; however, paraneoplastic arthropathies also arise as polyarthritis or polymyalgia, particularly in patients with myelomas, lymphomas, acute leukemia, and solid tumors. Because paraneoplastic syndromes, in some instances, might be manifested before a cancer diagnosis, they are difficult to diagnose and are often misdiagnosed. We experienced a 63-year-old female patient who had nonspecific arthritis on both hands and feet accompanied by fever. She had been diagnosed as rheumatoid arthritis and treated with prednisolone and disease modifying anti-rheumatic drugs (DMARDs) including methotrexate and anti-tumor necrosis factor agents. Her arthritis did not respond with anti-rheumatic treatment and diffuse large B-cell lymphoma was diagnosed by bone marrow biopsy. After 6 cycles of chemotherapy, her arthritis was improved as well as underlying lymphoma.
