Correlation between Expression of Peripheral IL-17 Protein and Aggression of Bipolar Mania.
- Author:
Hao-zhe LI
;
Wu HONG
;
Zuo-wei WANG
;
Cheng-mei YUAN
;
Ze-zhi LI
;
Jia HUANG
;
Chen ZHANG
;
Ning-ning LI
;
Zhi-guang LIN
;
Yi-ru FANG
- Publication Type:Journal Article
- MeSH:
Aggression/drug effects*;
Antipsychotic Agents/therapeutic use*;
Biomarkers/blood*;
Bipolar Disorder/drug therapy*;
Case-Control Studies;
Diagnostic and Statistical Manual of Mental Disorders;
Double-Blind Method;
Humans;
Interleukin-17/metabolism*;
Lithium Compounds/therapeutic use*;
Quetiapine Fumarate/therapeutic use*;
Treatment Outcome
- From:
Journal of Forensic Medicine
2016;32(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the correlation between the interleukin-17 (IL-17) level of peripheral blood and aggression of bipolar mania.
METHODS:Thirty-six patients of bipolar mania were selected as experimental group by DSM-IV-TR and received treatment with quetiapine and lithium. Thirty-six healthy volunteers with similar age and gender were selected as control group. The level of IL-17 at baseline in each group and the level of IL-17 in the experimental group after treatment for 2, 4 and 8 weeks were detected by ELISA.
RESULTS:The level of IL-17 in experimental group at baseline, after treatment for 2 and 4 weeks were all significantly higher than that in control group. After 8 weeks treatment, there was no significant difference between the two groups (P > 0.05). After 2, 4 and 8 weeks treatment, the total score and aggression score of Young Mania Rating Score (YMRS) were significantly lower than the baseline level (P < 0.05). In experimental group, the level of IL-17 was positively correlated with the two scores of YMRS at baseline (P < 0.05).
CONCLUSION:Bipolar mania may be related to the up-regulation of IL-17. The level of IL-17 is related to the severity of manic symptoms at baseline, especially aggression symptom.
