Changes of HCN4, Cx43 Expression in the Sinoatrial Node of Electric Shock Death.
- Author:
Xiao-feng CHEN
;
Dong LIANG
;
Qi HAN
;
Shi-feng ZHOU
;
Mao-jin ZHENG
;
Chao-qun WANG
- Publication Type:Journal Article
- MeSH:
Connexin 43/metabolism*;
Cyclic Nucleotide-Gated Cation Channels;
Heart Rate;
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism*;
Immunohistochemistry/methods*;
Myocardium/metabolism*;
Myocytes, Cardiac;
Sinoatrial Node/physiopathology*
- From:
Journal of Forensic Medicine
2015;31(4):266-268
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of hyperpolarization-activated cyclic nucleotide-gated cation channel 4 (HCN4) and connexin43 (Cx43) in the sinoatrial node of electric shock death.
METHODS:As experimental group, 34 cases of electric shock death who had definite current mark evidence were selected from pathology department of Xuzhou Medical College from 2010 to 2013. As the control group, 20 cases of fatal severe craniocerebral injury in traffic accidents were chosen. The expressions of HCN4 and Cx43 in the sinoatrial node were observed by immunohistochemical technology.
RESULTS:HCN4 positive cells expressed in the cell membrane and cytoplasm of the sinoatrial node. Cx43 positive cells expressed in the cell membrane and cytoplasm of T cells and myocardial cells. The expression of HCN4 was significantly higher than that of the control group (P < 0.05) and the expression of Cx43 was significantly lower than that of the control group (P < 0.05).
CONCLUSION:The changes of HCN4 and Cx43 expressions in the sinoatrial node illustrate electric shock death might be related to the abnormalities of cardiac electrophysiology and conduction.
