Effect of Heroin on DLG4 Expression in Hippocampus, Amygdala and Frontal Cortex of Rats.
- Author:
Liang-ming LUO
;
Qun GONG
;
Jian-feng LIU
;
Ming-quan ZHAO
;
Dong-dong CHEN
;
Yao-yao XIE
;
Hua ZHU
- Publication Type:Journal Article
- MeSH:
Amygdala/metabolism*;
Animals;
Disks Large Homolog 4 Protein;
Frontal Lobe/metabolism*;
Heroin/pharmacology*;
Heroin Dependence;
Hippocampus/metabolism*;
Injections, Intraperitoneal;
Intracellular Signaling Peptides and Proteins/metabolism*;
Membrane Proteins/metabolism*;
Rats
- From:
Journal of Forensic Medicine
2015;31(3):185-199
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression of discs large homolog 4 (DLG4) protein in hippocampus, amygdala and frontal cortex of rats and evaluate postsynaptic density in heroin dependence.
METHODS:The rat heroin dependent model was established by increasing intraperitoneal injection of heroin. DLG4 proteins in hippocampus, amygdala and frontal cortex of heroin dependent 9, 18, 36 days rats were detected with immunohistochemical staining and compared with that in the control group.
RESULTS:DLG4 proteins in hippocampus, amygdala and frontal cortex were gradually reduced with extension of heroin dependent time.
CONCLUSION:Heroin dependence can affect postsynaptic density of hippocampus, amygdala and frontal cortex. The changes become more apparent with extension of heroin dependence time.
