Expression and mechanism of alphaB-crystallin in retina and extraocular tissues and organs.
- Author:
Dong-mei LIU
;
Shu ZHOU
;
Jie-min CHEN
;
Shu-ya PENG
;
Wen-tao XIA
- Publication Type:Review
- MeSH:
Crystallins;
Gene Expression Regulation, Developmental;
Heat-Shock Proteins/metabolism*;
Humans;
Lens, Crystalline;
Retina;
alpha-Crystallin B Chain/metabolism*
- From:
Journal of Forensic Medicine
2014;30(6):470-473
- CountryChina
- Language:Chinese
-
Abstract:
alphaB-crystallin is the structural protein of vertebrate lens, which is widely expressed in non-lens tissue. As one of the heat shock protein family members, alphaB-crystallin possesses biological properties of molecular chaperones and anti-apoptotic effects. Multi-factor injuries, such as retinopathy, inflammation and nervous system diseases, have a closely relationship with alphaB-crystallin. This paper reviews the research progress of the expression and mechanism of alphaB-crystallin in retina and extraocular tissues and organs.
