Expression of monocyte chemotactic protein-1 and its receptor in sudden coronary death.
- Author:
Yuan-yuan KUANG
;
Xia-xia CHEN
;
Cang-cheng WANG
;
Kun YE
;
Ying WANG
;
Yong-hua SHI
- Publication Type:Journal Article
- MeSH:
Chemokine CCL2/metabolism*;
Coronary Artery Disease/pathology*;
Death, Sudden, Cardiac/pathology*;
Humans;
Immunohistochemistry;
Receptors, CCR2/metabolism*
- From:
Journal of Forensic Medicine
2014;30(6):413-418
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of monocyte chemotactic protein-1 (MCP-1) and its receptor CC chemokine receptor-2 (CCR-2) in coronary atherosclerosis plaques between sidden coronary death (SCD) and non-SCD. Methods The expression levels of MCP-1 and CCR-2 in SCD group, coronary atherosclerosis group (non-SCD), control group (normal coronary artery) were detected by immunohistochemistry.
RESULTS:Positive rates of MCP-1 among the three groups were 78%, 47%, and 0%, respectively, with significant expressing differences between each two groups (P<0.05). Positive rates of CCR-2 among three groups were 72%, 47%, and 0%, respectively, with significant expressing differences between the SCD group and coronary atherosclerosis group as well as between the SCD group and control group (P<0.05), but with no significant expressing difference between coronary atherosclerosis group and control group (P>0.05).
CONCLUSION:Overexpression of MCP-1 and CCR-2 in coronary atherosclerotic plaques is closely correlated with SCD.
