Time-related expression of IL-6, IL-8 and TNF-alpha following explosive injury to rabbit's chest.
- Author:
Meng HE
;
Li-Min DONG
;
Xiao-Bin HOU
- Publication Type:Journal Article
- MeSH:
Animals;
Enzyme-Linked Immunosorbent Assay;
Explosions;
Interleukin-6/metabolism*;
Interleukin-8/metabolism*;
Rabbits;
Thoracic Injuries/metabolism*;
Tumor Necrosis Factor-alpha/metabolism*
- From:
Journal of Forensic Medicine
2014;30(2):85-87
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between the expression changes of cytokines, interleukin-6 (IL-6), interleukin-8(IL-8), and tumor necrosis factor-alpha (TNF-alpha), and the wound time following explosive injury to rabbit's chest.
METHODS:The rabbit's model of explosive injury was established. The expression levels of IL-6, IL-8 and TNF-alpha in the plasma were detected by ELISA method at different wound time (0.5-12h).
RESULTS:The level of IL-6 increased at 3h after wounding and reached peak at 6 h. The level of IL-8 increased at 1 h and reached peak at 6 h. The level of TNF-alpha increased at 0.5 h and reached peak at 3 h.
CONCLUSION:IL-6, IL-8 and TNF-alpha have a time-related expression after explosive injury.
