Renal Denervation for Chronic Heart Failure: Background and Pathophysiological Rationale.
- Author:
Michael BÖHM
1
;
Sebastian EWEN
;
Felix MAHFOUD
Author Information
- Publication Type:Review
- Keywords: Congestive heart failure; Sympathetic nervous system; Neuroendocrine activation; Denervation
- MeSH: Arrhythmias, Cardiac; Comorbidity; Denervation*; Heart Failure*; Heart*; Hospitalization; Humans; Hypertension; Sleep Apnea, Obstructive; Sympathetic Nervous System
- From:Korean Circulation Journal 2017;47(1):9-15
- CountryRepublic of Korea
- Language:English
- Abstract: The activation of the sympathetic nervous system is associated with cardiovascular hospitalizations and death in heart failure. Renal denervation has been shown to effectively reduce sympathetic overdrive in certain patients with uncontrolled hypertension. Pilot trials investigating renal denervation as a potential treatment approach for heart failure were initiated. Heart failure comorbidities like obstructive sleep apnea, metabolic syndrome and arrhythmias could also be targets for renal denervation, because these occurrences are also mediated by the activation of the sympathetic nervous system. Therefore, renal denervation in heart failure is worthy of further investigation, although its effectiveness still has to be proven. Herein, we describe the pathophysiological rationale and the effect of renal denervation on surrogates of the heart failure syndrome.
