Genetic polymorphisms of 16 non-CODIS STR loci in Beijing Han population.
- Author:
Qing-Xia ZHANG
1
;
Jian YANG
;
Ya-Cheng LIU
;
Hui TANG
;
Zhang-Ping JIAO
Author Information
1. Forensic Science Service of the Beijing Public Security Bureau, Beijing 100192, China. qingxiazhang@sina.com
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian People/genetics*;
China;
DNA Fingerprinting;
Female;
Forensic Genetics;
Gene Frequency;
Genetic Markers;
Genetics, Population;
Heterozygote;
Humans;
Male;
Microsatellite Repeats;
Polymerase Chain Reaction;
Polymorphism, Genetic
- From:
Journal of Forensic Medicine
2013;29(3):206-208
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the genetic polymorphisms of 16 non-CODIS loci (D6S477, D22-GATA198B05, D15S659, D8S1132, D3S3045, D17S1290, D14S608, D2S441, D18S535, D13S325, D10S1435, DlS2368, DIS1656, D7S3048, D10S1248 and D19S253) in Beijing Han population.
METHODS:The DNA of 300 unrelated individuals in Beijing Han population were PCR amplified using GoldeneyeM DNA identification system 18NC kit, and the PCR products were analyzed by electrophoresis through 3130XL genetic analyzer. The fragment sizes of alleles were taken subsequently by GeneMapper v3.2.
RESULTS:The distributions of genotype frequencies of 16 non-CODIS STR loci in Beijing Han population satisfied the Hardy-Weinberg equilibration. The population genetic parameters were obtained as followings: heterozygosity was 0.677-0.873; discrimination power, 0.890-0.967; probability of paternity exclusion, 0.393-0.741; and polymorphism information content, 0.706-0.853.
CONCLUSION:These 16 non-CODIS STR loci show great genetic polymorphisms in Beijing Han population, and are useful for the research of population genetics and forensic application.
