The role and significance of microRNA in human cardiovascular disease and forensic science.
- Author:
Li-Liang LI
1
;
Zi-Qin ZHAO
Author Information
1. Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai 200032, China. 11111010016@fudan.edu.cn
- Publication Type:Review
- MeSH:
Animals;
Biomarkers/blood*;
Cardiomyopathy, Dilated/metabolism*;
Cardiovascular Diseases/metabolism*;
Cause of Death;
Death, Sudden, Cardiac/pathology*;
Forensic Sciences/methods*;
Gene Expression Profiling;
Gene Expression Regulation;
Heart Failure/metabolism*;
Humans;
MicroRNAs/metabolism*;
Myocardium/pathology*;
Pulmonary Embolism/diagnosis*;
Up-Regulation
- From:
Journal of Forensic Medicine
2013;29(1):39-42
- CountryChina
- Language:Chinese
-
Abstract:
microRNA (miRNA or miR) is a small single stranded non-coding RNA (21-25nt) that regulates gene expression in almost creatures. Currently, plenty of researches on how miRNA affects human cardiovascular disease have been reported. This review highlights recent findings about the role of miRNA in heart tissue and circulation correlated with human cardiovascular disease and explores the application of miRNA in sudden cardiac death in forensic science.
