Optimal Timing of Percutaneous Coronary Intervention for Nonculprit Vessel in Patients with ST-Segment Elevation Myocardial Infarction and Multivessel Disease.
- Author:
Inna KIM
1
;
Min Chul KIM
;
Hae Chang JEONG
;
Keun Ho PARK
;
Doo Sun SIM
;
Young Joon HONG
;
Ju Han KIM
;
Myung Ho JEONG
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Ki Bae SEUNG
;
Kiyuk CHANG
;
Youngkeun AHN
Author Information
- Publication Type:Original Article
- Keywords: Myocardial infarction; Percutaneous coronary intervention
- MeSH: Follow-Up Studies; Humans; Incidence; Jeollanam-do; Logistic Models; Mortality; Myocardial Infarction*; Percutaneous Coronary Intervention*; Retrospective Studies; Stroke Volume
- From:Korean Circulation Journal 2017;47(1):36-43
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND AND OBJECTIVES: In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD), the optimal timing of staged percutaneous coronary intervention (PCI) remains unclear. SUBJECTS AND METHODS: This study was a retrospective analysis of 753 STEMI patients with MVD who were treated by multivessel PCI in the Convergent Registry of Catholic and Chonnam University for Acute myocardial infarction (MI). Patients were divided into 3 groups according to the time from initial to staged PCI: group 1 (n=316, multivessel PCI performed during the index procedure), group 2 (n=360, staged PCI within 1 week), and group 3 (n=77, staged PCI after 1 week). The endpoint was major adverse cardiac events (MACEs), including all-cause mortality, non-fatal MI, and repeat PCI during 3.4 years follow-up. RESULTS: The incidence of composite MACEs was higher in group 3 than in group 1 (odds ratio [OR]: 1.83, 95% confidence interval [CI]: 1.06 to 3.18, p=0.031). However, the risk of MACEs in groups 1 and 2 was comparable (OR: 1.01, 95% CI: 0.70 to 1.46, p=0.950). In multivariate logistic regression, independent predictors of 3-year MACEs were high Killip class (OR: 2.72, 95% CI: 1.38 to 5.37, p=0.004), left ventricular ejection fraction <45% (OR: 1.57, 95% CI: 1.06 to 2.32, p=0.024), and group 3 (OR: 1.83, 95% CI: 1.06 to 3.18, p=0.009). CONCLUSION: Deferred staged PCI after one week index PCI was associated with the highest MACE, as compared to both simultaneous multivessel PCI and early staged PCI <1 week.
