Relationship between genetic polymorphisms of 3 SNP loci in 5-HTT gene and paranoid schizophrenia.
- Author:
Jin-Feng XUAN
1
;
Mei DING
;
Hao PANG
;
Jia-Xin XING
;
Yi-Hua SUN
;
Jun YAO
;
Yi ZHAO
;
Chun-Mei LI
;
Bao-Jie WANG
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang 110001, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Asian People/genetics*;
Case-Control Studies;
Female;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Haplotypes;
Humans;
Male;
Polymerase Chain Reaction/methods*;
Polymorphism, Single Nucleotide/genetics*;
Schizophrenia, Paranoid/genetics*;
Serotonin Plasma Membrane Transport Proteins/genetics*
- From:
Journal of Forensic Medicine
2012;28(6):418-421
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the population genetic data of 3 SNP loci (rs25533, rs34388196 and rs1042173) of 5-hydroxytryptamine transporter (5-HTT) gene and the association with paranoid schizophrenia.
METHODS:Three SNP loci of 5-HTT gene were examined in 132 paranoid schizophrenia patients and 150 unrelated healthy individuals of Northern Chinese Han population by PCR-RFLP technique. The Hardy-Weinberg equilibrium test was performed using the chi-square test and the data of haplotype frequency and population genetics parameters were statistically analyzed.
RESULTS:Among these three SNP loci, four haplotypes were obtained. There were no statistically significant differences between the patient group and the control group (P > 0.05). The DP values of the 3 SNP loci were 0.276, 0.502 and 0.502. The PIC of them were 0.151, 0.281 and 0.281. The PE of them were 0.014, 0.072 and 0.072.
CONCLUSION:The three SNP loci and four haplotypes of 5-HTT gene have no association with paranoid schizophrenia, while the polymorphism still have high potential application in forensic practice.
