Association and its forensic significance between COMT gene and schizophrenia.
- Author:
Chun-Li DING
1
;
Xue ZHOU
;
Bao-Jie WANG
;
Mei DING
;
Hao PANG
Author Information
1. Key Laboratory of Evidence Identification in Universities of Shandong, Shandong University of Political Science and Law, Jinan 250014, China. lichun999_@126.com
- Publication Type:Review
- MeSH:
Aggression/psychology*;
Brain/pathology*;
Catechol O-Methyltransferase/genetics*;
Cognition/physiology*;
Dopamine/metabolism*;
Forensic Genetics;
Gene Expression;
Genetic Predisposition to Disease;
Genetic Variation;
Genotype;
Haplotypes;
Humans;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Prefrontal Cortex/pathology*;
Promoter Regions, Genetic;
Schizophrenia/genetics*;
Violence/psychology*
- From:
Journal of Forensic Medicine
2012;28(4):299-304
- CountryChina
- Language:Chinese
-
Abstract:
Catechol-O-methyltransferase (COMT) gene encodes catechol-O-methyltransferase, the variant of this gene may affect the expression and metabolic activity of COMT. As the result of the changes of the effective concentration of the catecholamine neurotransmitter in the central nervous system, central nervous system dysfunctions associated with schizophrenia. This review summarizes genetic polymorphism and diversity of COMT gene. It also elaborates the relation between SNP and haplotype of COMT gene and three aspects, which including schizophrenia, attacking and violent tendency, and the frontal cognitive function of the schizophreniac. The correlativity study between genetic variation of the COMT gene and schizophrenia in patients with attacking and violent tendency may be helpful for the assessment of forensic psychiatry.
