Expression of FAPalpha and TGF-beta1 in sudden deaths due to acute myocardial ischemia.
- Author:
Xiang-Tian YUAN
1
;
Xue PENG
;
Zhan-Feng JIN
Author Information
1. Detachment of Criminal Science and Technology, Public Security Bureau of Hulunbuir, Hulunbuir 021008, China. wjyxt@sina.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Acute Disease;
Adult;
Aged;
Aged, 80 and over;
Autopsy;
Death, Sudden, Cardiac;
Endopeptidases;
Female;
Forensic Pathology;
Gelatinases/metabolism*;
Humans;
Immunohistochemistry;
Male;
Membrane Proteins/metabolism*;
Middle Aged;
Myocardial Infarction/pathology*;
Myocardial Ischemia/pathology*;
Myocardium/metabolism*;
Myocytes, Cardiac/metabolism*;
Recurrence;
Retrospective Studies;
Serine Endopeptidases/metabolism*;
Transforming Growth Factor beta1/metabolism*
- From:
Journal of Forensic Medicine
2012;28(1):18-20
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression of fibroblast activation protein alpha (FAPalpha) and transforming growth factor-beta1 (TGF-beta1) in myocardial cytoplasm for the cases of sudden death due to acute myocardial ischemia.
METHODS:The heart tissues of 47 cases were collected. All cases were divided into three groups: control group, acute myocardial infarction group and recurrent myocardial infarction group. FAPalpha and TGF-beta1 expressions were explored in myocardial cytoplasm by immunohistochemistry technology. The staining results were collected by image analysis system and then the positive area ratio and average optical density were detected. The positive signal differences were compared among the groups.
RESULTS:Strong FAPalpha and TGF-beta1 expressions were detected in myocardial cytoplasm in both acute and recurrent myocardial infarction groups. The expression of FAPalpha was not detected in myocardial cytoplasm in control group and TGF-beta1 expression showed a weak positive result. FAPalpha and TGF-beta1 expressions showed the statistical difference (P < 0.05) in myocardial infarction (acute and recurrent) groups and control group.
CONCLUSION:FAPalpha and TGF-beta1 can be the diagnostic markers for determing acute myocardial infarction.
