The expression of GABA(A) receptor alpha1 and GABA(B) receptor 1 in medulla oblongata solitary nucleus and ambiguous nucleus in the cases of tramadol intoxication.
- Author:
Shu ZHANG
1
;
Da-Wei GUAN
;
Ling WANG
;
Hua-Xin WANG
;
Guo-Hua ZHANG
;
Rui ZHAO
;
Yan-Yan FAN
Author Information
1. Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China. shuzhang0506@126.com
- Publication Type:Journal Article
- MeSH:
Adult;
Analgesics, Opioid/poisoning*;
Autopsy;
Case-Control Studies;
Cause of Death;
Female;
Forensic Toxicology;
Humans;
Immunohistochemistry;
Male;
Medulla Oblongata/metabolism*;
Receptors, GABA-A/metabolism*;
Receptors, GABA-B/metabolism*;
Respiration Disorders/etiology*;
Solitary Nucleus/metabolism*;
Staining and Labeling;
Tramadol/poisoning*
- From:
Journal of Forensic Medicine
2011;27(6):401-404
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression of GABA(A) receptor alpha1 (GABA(A)alpha1) and GABA(B) receptor 1 (GABA(B)1) in human medulla oblongata solitary nucleus and ambiguous nucleus due to tramadol-induced death.
METHODS:GABA(A)alpha1 and GABA(B)1 were detected by immunohistochemical SP method in tramadol-induced death group and control group. All results were evaluated by images analysis system.
RESULTS:Low expression of GABA(A)alpha1 and GABA(B)1 were detected in solitary nucleus and ambiguous nucleus in the control brain tissue. In cases of tramadol-induced death, the expression of GABA(A)alpha1 and GABA(B)1 significantly increased.
CONCLUSION:The mechanism of tramadol intoxication death could be caused by respiratory depression induced by over-expression of GABA(A)alpha1 and GABA(B)1 in medulla oblongata solitary nucleus and ambiguous nucleus.
