Application of brain natriuretic peptide in evaluation of cardiac function in forensic medicine.
- Author:
Wei-Min GAO
1
;
Rui-Ming MAO
;
Zhong-Bo DU
;
Li MI
;
Bao-Ll ZHU
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang 110001, China. shangyigaoweimin@126.com
- Publication Type:Review
- MeSH:
Amino Acid Sequence;
Animals;
Autopsy;
Biomarkers;
Death, Sudden, Cardiac;
Forensic Pathology;
Heart Diseases/physiopathology*;
Heart Failure/physiopathology*;
Humans;
Immunohistochemistry;
Molecular Sequence Data;
Myocardium/pathology*;
Natriuretic Peptide, Brain/metabolism*;
Peptide Fragments/metabolism*;
Pericardium/metabolism*;
Postmortem Changes;
RNA, Messenger/metabolism*
- From:
Journal of Forensic Medicine
2011;27(5):369-375
- CountryChina
- Language:Chinese
-
Abstract:
Brain natriuretic peptide (BNP) is a major marker for evaluating cardiac function and has been widely used in clinical practice. Recent researches show that BNP is also useful for identification of sudden cardiac death in forensic pathology. This article reviews the molecular structure and biological characteristics of the BNP and its application as a functional indicate in forensic medicine. It shows that the expression of BNP in cardiac muscles, together with the expression of BNP in blood and pericardium liquid can be used to evaluate the pathological physiology changes and dysfunction degrees of the heart during the cardiac sudden death.
