Relationship between cholecystokinin gene -45C/T polymorphism and schizophrenia and its application in forensic medicine.
- Author:
Jun YANG
1
;
Mei DING
;
Yin SUN
;
Hao PANG
;
Jia-xin XING
;
Jin-feng XUAN
;
Chun-mei LI
;
Bao-jie WANG
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang 110001, China. yangliu03170015@163.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Alleles;
Asian People/genetics*;
Case-Control Studies;
China;
Cholecystokinin/genetics*;
Female;
Forensic Genetics;
Forensic Psychiatry;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Male;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Schizophrenia/genetics*;
Sequence Analysis, DNA
- From:
Journal of Forensic Medicine
2011;27(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the polymorphism of cholecystokinin (CCK) gene -45C/T of schizophrenia and its application in forensic medicine.
METHODS:Bidirectional allele specific PCR was used to detect CCK gene -45C/T polymorphisms in 207 schizophrenic patients (case group) and 202 healthy individuals (control group) of the Han population in northern China. The chi2 test was used to identify Hardy-Weinberg equilibrium of the genotype distribution in control group. The differences of genotype and allele frequencies distributions were compared between two groups.
RESULTS:Distributions of the genotype frequencies satisfied the law of Hardy-Weinberg equilibrium in control group. The differences between genotypic frequencies and allele frequencies were not statistical significance in case group and control groups (P > 0.05). Gender-stratified analysis showed that frequency of allele T in female case group was statistically higher than that in female control group (P = 0.044).
CONCLUSION:CCK gene -45C/T locus T allele may be positively associated with schizophrenia in female population and useful in schizophrenia identification.
