Gastric Adenocarcinoma with Coexistent Hepatoid Adenocarcinoma and Neuroendocrine Carcinoma: A Case Report.
10.4132/KoreanJPathol.2009.43.1.79
- Author:
Aeri KIM
1
;
Sang Woon KIM
;
Sun Kyo SONG
;
Young Kyung BAE
Author Information
1. Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. ykbae@ynu.ac.kr
- Publication Type:Case Report
- Keywords:
Gastric cancer;
AFP;
Hepatocellular carcinoma;
Neuroendocrine carcinoma
- MeSH:
Adenocarcinoma;
Aged;
alpha-Fetoproteins;
Carcinoma, Hepatocellular;
Carcinoma, Neuroendocrine;
Gastrectomy;
Humans;
Lymph Node Excision;
Stomach;
Stomach Neoplasms;
Synaptophysin
- From:Korean Journal of Pathology
2009;43(1):79-82
- CountryRepublic of Korea
- Language:English
-
Abstract:
This report represents a very rare case of a gastric adenocarcinoma that was coexistent with hepatoid adenocarcinoma and neuroendocrine carcinoma. A 77-year-old man was admitted to our hospital due to a huge ulcerofungating mass identified at the proximal body of the stomach. After a pathological diagnosis of the tumor as a poorly differentiated adenocarcinoma was made, the patient underwent a total gastrectomy with lymph node dissection. Microscopically, the tumor consisted of three morphologically distinct components-tubular adenocarcinoma, hepatoid adenocarcinoma and neuroendocrine carcinoma. The hepatoid adenocarcinoma component resembled a hepatocellular carcinoma and produced alpha-fetoprotein. The neuroendocrine carcinoma component was positive for chromogranin and synaptophysin immunostains. This is an example of the diverse morphological and immunophenotypical differentiation of gastric carcinomas.
