Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy.
- Author:
Hong-Fei XU
1
;
Jian-Lei CHEN
;
Xu-Ping DA
;
Ke-Rong WU
;
Guo-Qing LIU
;
Zi-Qin ZHAO
;
Xin-Hua HAN
Author Information
1. Department of Forensic Medicine, Medical College of Nantong University, Nantong 226001, China. whhongfei@sina.com
- Publication Type:Journal Article
- MeSH:
Cardiomyopathy, Dilated/pathology*;
Case-Control Studies;
Coxsackie and Adenovirus Receptor-Like Membrane Protein;
Coxsackievirus Infections/complications*;
Death, Sudden, Cardiac;
Female;
Forensic Pathology;
Humans;
Immunohistochemistry;
Male;
Myocarditis/virology*;
Myocardium/pathology*;
Receptors, Virus/metabolism*;
Staining and Labeling
- From:
Journal of Forensic Medicine
2010;26(5):328-331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death, pathogenesis and relationship between the viral myocarditis (VMC) and dilated cardiomyopathy (DCM) were investigated.
METHODS:Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples, including 22 deceased with VMC, 20 deceased with DCM and 16 control deceased.
RESULTS:The brown staining on the cell membrane of myocardium showed positive result. There was a prominent CAR expression in VMC group and DCM group, which were statistically significant difference compared with control group (P < 0.05).
CONCLUSION:The CAR expression showed significantly higher in VMC and DCM groups. The viral infection can result in myocardial necrosis and impaired cardiac functions. These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.
