Advancement of methanol poisoning mechanism research.
- Author:
Jie-min CHEN
1
;
Li-xin WANG
;
Wen-tao XIA
Author Information
1. Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai 200032, China.
- Publication Type:Review
- MeSH:
Acidosis/chemically induced*;
Animals;
Formaldehyde/poisoning*;
Formates/poisoning*;
Free Radicals/metabolism*;
Humans;
Methanol/poisoning*;
Nervous System/pathology*;
Oxidoreductases Acting on CH-NH Group Donors/metabolism*;
Proteins/metabolism*;
Vision Disorders/pathology*
- From:
Journal of Forensic Medicine
2010;26(4):294-296
- CountryChina
- Language:Chinese
-
Abstract:
The methanol poisoning by oral intake or skin contact occurs occasionally, which may have serious consequences including blindness and/or death. Methanol and its metabolites, formaldehyde and formic acid, are associated with metabolic acidosis, visual dysfunction and neurological symptoms. At present, the mechanism of methanol poisoning primarily focuses on the cell hypoxia, the alteration of structure and biological activity induced by free radical and lactic acid. Meanwhile, methanol poisoning causes changes in the balance between the production of free radicals and antioxidant capacity and in the proteases-protease inhibitors system, which lead to a series of disturbances.
