Applications of Alu family in forensic DNA analysis.
- Author:
Gui-sen ZHAO
1
;
Lin CHANG
;
Yao-nan MO
Author Information
1. Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing 100088, China. aifuhong@yahoo.com.cn
- Publication Type:Review
- MeSH:
Alu Elements/genetics*;
Base Sequence;
Chromosomes, Human/genetics*;
DNA/genetics*;
DNA Methylation;
Forensic Genetics/methods*;
Genetic Markers;
Genome, Human;
Humans;
Polymerase Chain Reaction;
Polymorphism, Genetic/genetics*;
Sensitivity and Specificity;
Sequence Analysis, DNA
- From:
Journal of Forensic Medicine
2010;26(1):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Alu family is the primate specific short interspersed repetitive elements (SINEs). Its abundance and diversity distribution in genome, high methylation level and polymorphic for insertion make them ideally suitable as tools in forensic applications. The application of A4 lu sequence in forensic genomics, include DNA quantitation, race determination, species and gender identification, personal identification, paternity testing and whole-genome amplification. The principles and characteristics of these Alu-based techniques are also summarized. The prospect of Alu as forensic molecular marker is discussed as well.
