The influence of estazolam on human neurobehavioral function.
- Author:
Jun BU
1
;
Xian-yi ZHUO
Author Information
1. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, PR China, Shanghai 200063, China.
- Publication Type:Journal Article
- MeSH:
Accidents, Traffic/prevention & control*;
Administration, Oral;
Adult;
Anticonvulsants/pharmacokinetics*;
Attention/drug effects*;
Behavior/drug effects*;
Estazolam/pharmacokinetics*;
Female;
Humans;
Male;
Neuropsychological Tests;
Psychomotor Performance/drug effects*;
Reaction Time
- From:
Journal of Forensic Medicine
2010;26(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the relation between human blood estazolam concentration and neurobehavioral function.
METHODS:The neurobehavioral ability of 10 volunteers were measured with computer-administered neurobehavioral evaluation system-chinese3 (NES-C3) and SMART EquiTest system.
RESULTS:The neurobehavioral ability and balance function declined 1 h later after dosing estazolam. The neurobehavioral ability index and balance function declined to the lowest level 3 h later after dosing estazolam. The neurobehavioral ability recovered partly 6 h later after dosing estazolam, and neurobehavioral ability recovered completely 10 h later.
CONCLUSION:Driving ability was impaired when estazolam concentration in blood is 20 ng/mL, and the neurobehavioral ability declined when estazolam concentration is 40 ng/mL in blood. The influence to human in absorption process is greater than the metabolic process with the same estazolam concentration.
