The value of TNFalpha testing in evaluation of death due to drug anaphylactic shock.
- Author:
Yong-Liang HU
1
;
Jian-Hua ZHU
;
Hua-Lan JING
Author Information
1. The Third Department of Medicine, Wannan Medical College, Wuhu, China. wanyi.hu@163.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Anaphylaxis/pathology*;
Autopsy;
Cause of Death;
Child;
Child, Preschool;
Drug Hypersensitivity;
Enzyme-Linked Immunosorbent Assay;
Female;
Forensic Pathology;
Humans;
Infant;
Male;
Middle Aged;
Tumor Necrosis Factor-alpha/blood*;
Young Adult
- From:
Journal of Forensic Medicine
2009;25(5):332-333
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the changes of the serum TNFalpha level in cadavers of drug anaphylactic shock(DAS) and to explore the significance of the TNFalpha testing in evaluation of death caused by DAS.
METHODS:The level of serum TNFalpha from cardiac blood was determined by double antibody-sandwich ELISA method.
RESULTS:The level of TNFalpha in the experimental group was (131.6+/-9.4) pg/mL, while the level in the infectious diseases control group and the normal control group were (87.3+/-6.4) pg/mL and (17.2+/-4.5) pg/mL, respectively. There was statistically significant difference among the groups (P<0.05).
CONCLUSION:The serum TNFalpha level may be used as one of the indexes for evaluation of death caused by highly suspected drug anaphylactic shock.
