The pathological observation of acute intoxication by Alangium Chinese in mice.
- Author:
Chang-Yin ZHANG
1
;
Li-Jun ZHANG
;
Yong-Liang HU
;
Xian-Dong XIA
;
Lin-Ming LU
;
Yi-Feng YAN
;
Xiang XU
;
Wei KE
;
Jian-Hua ZHU
Author Information
1. Chizhou Qiucheng Forensic Judical Appraisal Institute, Chizhou, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Alangiaceae/chemistry*;
Animals;
Brain/pathology*;
Disease Models, Animal;
Dose-Response Relationship, Drug;
Female;
Forensic Pathology;
Hemorrhage/pathology*;
Hepatocytes/drug effects*;
Kidney/pathology*;
Lethal Dose 50;
Liver/pathology*;
Lung/pathology*;
Male;
Mice;
Muscle, Smooth, Vascular/drug effects*;
Plant Extracts/toxicity*;
Plant Roots/chemistry*;
Random Allocation;
Toxicity Tests, Acute
- From:
Journal of Forensic Medicine
2009;25(5):329-331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the pathological change of mice organ intoxicated by Alangium Chinese and its poisoning mechanism.
METHODS:Mice were intoxicated by gavage with extract of Alangium Chinese. Then the histopathologic examination was made for evaluating the pathological changes in the organs of the poisoned mice by HE staining.
RESULTS:The main pathological changes included alveolar hemorrhage, pulmonary interstitial hemorrhage, sinus hepaticus expansion and congestion, hepatocyte edema, subarachnoid hemorrhage, congestion and hemorrhage of other organs.
CONCLUSION:The main target organs or tissue of Alangium Chinese are the lungs, liver and vascular smooth muscle. There is correlation between the toxic effect and the dosage.
