Effects of curcumin on malondialdehyde and c-fos protein in hypoxia ischemia brain tissue in rats.
- Author:
Yuan-yuan ZHENG
1
;
Lin-sheng YU
;
Yi-gu ZHANG
;
Guang-hua YE
;
Ji-pu YI
Author Information
1. Department of Forensic Medicine, Wenzhou Medical College, Wenzhou 325035, China. yyzdxno@163.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Curcumin/pharmacology*;
Forensic Pathology;
Hypoxia-Ischemia, Brain/pathology*;
Male;
Malondialdehyde/metabolism*;
Neurons/pathology*;
Neuroprotective Agents/pharmacology*;
Proto-Oncogene Proteins c-fos/metabolism*;
Random Allocation;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Forensic Medicine
2009;25(1):6-8
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of curcumin on the content of malondialdehyde (MDA) and the expression level of c-fos protein following hypoxia ischemia brain damage (HIBD) in rats.
METHODS:Sprague-Dauley (SD) rats were randomly divided into four groups as the following: sham group, hypoxia ischemia brain damage group, curcumin group and solvent control group. The content of MDA in the brain was measured by colorimetry. The expression level of c-fos protein in the cortex tissue was detected by immunohistochemistry. Morphologic and structural changes of neuron cells of the cortex were observed by electron microscopy.
RESULTS:The content of MDA was clearly lower in curcumin group than that in the other groups at the same time after HIBD. The expression level of c-fos protein was higher in the curcumin group than that in the other groups (P<0.05). Electron microscopy showed that the morphologic and structural changes of neuron cells of cortex in the curcumin group were reduced.
CONCLUSION:Curcumin could significantly decrease the content of MDA, increase the expression level of c-fos protein and reduce the damage of the neuron cells.
