Expression of Fas protein in myocardiac tissue of viral myocarditis and dilated cardiomyopathy.
- Author:
Xiao-Qiao WU
1
;
Yong-Hong LI
;
Xian ZHU
;
Mao-Wang WU
;
Sheng-Ming HU
Author Information
1. The Third Department of Medicine, Wanan Medical College, Wuhu 241001, China. wxiaoqiao@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Apoptosis/physiology*;
Cardiomyopathy, Dilated/pathology*;
Case-Control Studies;
Female;
Forensic Pathology;
Humans;
Male;
Myocarditis/virology*;
fas Receptor/metabolism*
- From:
Journal of Forensic Medicine
2008;24(6):414-416
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pathogenesis of viral myocarditis (VMC) and dilated cardiomyopathy (DCM) and their relationship.
METHODS:Sixty samples including 20 VMC, 20 DCM and 20 controls were collected. The expression of Fas protein in myocardium of each group was detected by modified immunohistochemistry with unequivocal brown staining in the myocardial membrane scored as positive, and the results of positive reaction were analyzed by Ridit test.
RESULTS:Fas protein expression increased obviously in VMC and DCM groups as compared with that of the control group. The difference of positive results between each group analyzed by Ridit test was statistically significant (P<0.005). Statistically significant differences were found between VMC and control groups as well as between DCM and control groups (P<0.05), but not between VMC and DCM groups (P>0.05) by multiple comparison Ridit test.
CONCLUSION:The expression of Fas protein is significantly higher in the VMC and DCM groups than in that of the control group. These results suggest that both the VMC and DCM may share a similar pathogenesis, which most likely involves cell apoptosis.
