The association of tyrosine hydroxylase gene polymorphism with mental disorder.
- Author:
Jian YU
1
;
Hao PANG
;
Bao-Jie WANG
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang 110001, China. yujian0905@sina.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Depressive Disorder/genetics*;
Female;
Forensic Genetics;
Humans;
Male;
Mental Disorders/genetics*;
Polymorphism, Single Nucleotide/genetics*;
Schizophrenia/genetics*;
Tyrosine 3-Monooxygenase/genetics*
- From:
Journal of Forensic Medicine
2008;24(5):333-335
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the relationship between the tyrosine hydroxylase (TH) gene and mental disorder by comparing the two TH gene SNP points (extron 3 and intron 9) of patients with mental disorders and normal human.
METHODS:DNA extracted from specimens of patients and normal subjects were quantified by using Real-time PCR.
RESULTS:(1) G334A distribution was: G=0.133, A=0.867 in patients with schizophrenia, G=0.116, A=0.884 in patients with depression, and G=0.214, A=0.786 in normal group. (2) C5162G distribution was: C=0.962, G=0.038 in patients with schizophrenia, C=0.959, G=0.041 in patients with depression, and C=0.961, G=0.039 in normal group.
CONCLUSION:There are statistically significant differences in G334A locus between normal people and patients with mental disorders, but no statistically significant differences in C5162G locus.
