Changes of phospho-JNK expression during the skin burned wound healing.
- Author:
Chang-Yan XIONG
1
;
Da-Wei GUAN
;
Zhi-Hui LIU
;
Bo ZHEN
;
Rui ZHAO
;
Bao-Li ZHU
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang 110001, China.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Adult;
Burns/enzymology*;
Female;
Forensic Medicine;
Humans;
JNK Mitogen-Activated Protein Kinases/metabolism*;
Male;
Middle Aged;
Phosphorylation;
Random Allocation;
Skin/injuries*;
Wound Healing
- From:
Journal of Forensic Medicine
2008;24(5):325-335
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the changes of expression of phosphorylation c-Jun NH2-terminal kinase (p-JNK) during the skin burned wound healing in patients and discuss the molecular mechanism of burned wound healing.
METHODS:The staining intensity and distribution of p-JNK were detected by immunohistochemistry and routine histology in burned skin samples of 12 patients and normal skin samples of 12 control subjects.
RESULTS:In normal skin, the positive signals of p-JNK were mostly localized in basal layer cells of the epidermis, with a positive rate of (8.8+/-1.3)%. In the burned group, the positive signals of p-JNK were mainly localized in the epidermal cells and some inflammatory cells, with a significantly higher positive rate of (31.2+/-3.3)% than the normal group(P<0.01).
CONCLUSION:The changes of p-JNK expression after skin burned might correlate with wound healing.
