The relationship between SNP of cholecystokinin gene and certain mental status and its forensic significance.
- Author:
Jun YANG
1
;
Bao-jie WANG
;
Mei DING
;
Hao PANG
;
Xue-fei SUN
;
Zhong-jie LI
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang 110001, China. yangliu03170015@163.com
- Publication Type:Review
- MeSH:
Cholecystokinin/genetics*;
Forensic Medicine;
Humans;
Mental Disorders/genetics*;
Polymorphism, Single Nucleotide/genetics*;
Psychiatric Status Rating Scales
- From:
Journal of Forensic Medicine
2008;24(4):284-287
- CountryChina
- Language:Chinese
-
Abstract:
Cholecystokinin (CCK) is a brain-gut peptide with broad biological activities. It is one of the main regulating hormones in the digestive system, and it plays an important physiological role in the central and peripheral nervous system as a neurotransmitter or a neuromodulator. Recently, many reports have demonstrated that there were a number of SNPs on CCK gene, of which -45C/T and -196G/A showed certain correlation with a variety of psychiatric states such as schizophrenia, depressive disorder, suicidal behavior, Parkinson's disease, etc. These SNPs may be used in paternity testing and personal identification. In addition, it may also become one of the auxiliary indicators in some special cases of forensic pathology.
