Acute necrotizing pancreatitis and postmortem autolysis of pancreas.
- Author:
Guang-Hua YE
1
;
Yi-Gu ZHANG
;
Lin-Sheng YU
;
Xing-Biao LI
;
Jun-Ge HAN
Author Information
1. Department of Forensic Medicine, Wenzhou Medical College, Wenzhou 325035, China. yeghua345@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Autolysis;
Female;
Forensic Pathology;
Male;
Pancreas/pathology*;
Pancreatitis, Acute Necrotizing/pathology*;
Poisoning/pathology*;
Postmortem Changes;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Forensic Medicine
2008;24(2):94-101
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the pathomorphologic changes between the pancreas in acute necrotizing pancreatitis (ANP) and that in acute deaths of rats (within 48 hours) so as to find the distinctions.
METHODS:The animal models of ANP and other acute deaths (electroshock, mechanic asphyxia/strangle, and acute poisoning with tetramine) were established according to the criteria. Half-quantitative grading and image quantitative analysis methods were employed to observe the gross and microscopic changes of the pancreases.
RESULTS:Three features including inflammation infiltrate, fat necrosis and calcium deposit in the ANP group were considerably different from that in other acutely died rat group (P<0.05).
CONCLUSION:Inflammation infiltrate, fat necrosis and calcium deposit are the most important pathologic features found in ANP by common light microscope, distinguishing ANP from postmortem pancreatic autolysis.
