Coma criterion and classification standard of mild and moderate traumatic brain injury in rats.
- Author:
Jian-Yun YU
1
;
Jun-Xiang LI
;
Ze-Yun' GUO
;
Xiao-Lin ZHAO
;
Xu-Dong ZHAO
Author Information
1. Department of Forensic Medicine, Kunming Medical College, Kunming 650031, China. jianyunyu@sina.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Brain Injuries/pathology*;
Coma/etiology*;
Forensic Medicine;
Male;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Forensic Medicine
2008;24(1):8-11
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To set up a classification standard of mild and moderate traumatic brain injury, for the purpose of reliable data comparison derived from different laboratories.
METHODS:Traumatic brain injury (TBI) in rats was prepared by using a metallic pendulum-striker device. After injury, five variable parameters including the time of apnea and the areflexia, time of corneal reflex, external auditory canal stung reaction, body-righting reflex and needling reaction were determined and scored by using rat coma criterion. These data were judged and classified into mild and moderate head injury by brain patho-anatomy changes. Then the data were used to set up a multivariate discriminate equation.
RESULTS:The distinguished probability of mild and moderate TBI according to actual direct measured value and the criterion were 88.9% and 91.9%, respectively.
CONCLUSION:This method is able to classify mild and moderate TBI in rats.
