Distribution of tryptophan hydroxylase gene-T457C locus polymorphism in Han ethnic group in northern China.
- Author:
Hong-Yu GUAN
1
;
Bao-Jie WANG
;
Mei DING
;
Hao PANG
;
Bin WANG
;
Hong-Tao LU
;
Jia-Xin XING
;
Jin-Feng YI
;
Chun-Mei LI
Author Information
1. School of Forensic Medicine, China Medical University, Shenyang, China.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Alleles;
Asian People/genetics*;
China/ethnology*;
Electrophoresis, Polyacrylamide Gel;
Gene Frequency;
Genotype;
Humans;
Polymerase Chain Reaction/methods*;
Polymorphism, Genetic;
Sequence Analysis, DNA;
Tryptophan Hydroxylase/genetics*
- From:
Journal of Forensic Medicine
2007;23(6):444-445
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the distribution of the tryptophan hydroxylase (TPH) gene-T457C locus polymorphism in Han ethnic group in northern China and to find its applicable value in forensic science.
METHODS:Genomic DNA samples, extracted from 180 unrelated individuals in northern Chinese Han population, were analyzed by PCR-RFLP.
RESULTS:The discrimination power (DP) value and the power of exclusion (PE) value of the TPH gene-T457C locus were 0.624 and 0.187, respectively. The allele frequency showed significant difference from that of French people (P=0.04).
CONCLUSION:Polymorphism of the TPH gene-T457C locus could show ethnic and regional differences. It has a potential to be used in forensic science.
