The role of dopamine D3 receptor in the amphetamine-induced conditioned place preference in mice.
- Author:
Jun-Yan ZHU
1
;
Li-Ping CHEN
;
Lin LI
;
Hai-Bo ZHENG
;
Teng CHEN
Author Information
1. Department of Forensic Medicine, Medical College, Xi'an Jiaotong University, Xi'an 710061, China. zhujunyan@163.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Amphetamine/pharmacology*;
Animals;
Behavior, Animal/drug effects*;
Conditioning, Operant/drug effects*;
Disease Models, Animal;
Female;
Gene Knockout Techniques;
Male;
Mice;
Mice, Inbred C57BL;
Mice, Knockout;
Motor Activity/drug effects*;
Reaction Time;
Receptors, Dopamine D3/physiology*
- From:
Journal of Forensic Medicine
2007;23(6):428-430
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the role of dopamine D3 receptor involved in the amphetamine-induced conditioned place preference (CPP) in mice.
METHODS:The CPP was observed in D3 receptor knock-out (D3RKO) mice and C57BL/6 wild-type control mice after administration of amphetamine. The data were analyzed with a two-way ANOVA using the SPSS 13.0 software.
RESULTS:D3RKO mice showed a significant amphetamine-induced CPP (P<0.001), compared with the ones administered with saline in C57BL/6 control mice.
CONCLUSION:The results indicate that amphetamine can produce significant CPP in dopamine D3 receptor knock-out mice, suggesting that amphetamine-induced addiction can be inhibited by dopamine D3 receptor.
