Estimation of postmortem interval with multivoxel-voxel proton 1H-MR spectroscopy.
- Author:
Tian-Tong YANG
1
;
Zhen-Wei LI
;
Liang LIU
;
Na ZHENG
Author Information
1. Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yttwowo@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Aspartic Acid/metabolism*;
Biomarkers/metabolism*;
Brain/pathology*;
Choline/metabolism*;
Creatine/metabolism*;
Disease Models, Animal;
Embolism, Air;
Female;
Magnetic Resonance Spectroscopy/methods*;
Male;
Phosphocreatine/metabolism*;
Postmortem Changes;
Protons;
Rabbits;
Regression Analysis;
Time Factors
- From:
Journal of Forensic Medicine
2007;23(6):405-408
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The purpose of our study was to evaluate the postmortem interval with multi-voxel 1H-MR spectroscopy.
METHODS:Twelve healthy rabbits were studied and the quantities of N-acetylaspartate, total choline, phosphocreatine and creatine were measured by 1H-MR spectroscopy after death at 0.5, 1, 2, 4, 6, 8, 12, 16, and 24 h.
RESULTS:The levels of Naa/Cr and Naa/Ch decreased following death, while the level of Ch/Cr increased initially and then decreased following death.
CONCLUSION:Multi-voxel proton MR spectroscopy for Naa/Cr and Ch/Cr metabolic ratio could be used in future postmortem interval studies.
