Application of D6S1043 and D12S391 loci in forensic paternity testing.
- Author:
Hong GUO
1
;
Yuan LIN
;
Yan LIU
;
Ting-zhi QUE
;
Pin-hua YAN
;
Zhen-min ZHAO
;
Cheng-tao LI
;
Li LI
Author Information
1. Medical School of Soochow University, Suzhou 215123, China. fyguo-2005@163.com
- Publication Type:Journal Article
- MeSH:
Alleles;
China/ethnology*;
DNA Fingerprinting/methods*;
Electrophoresis, Capillary;
Forensic Medicine/methods*;
Gene Frequency;
Genetics, Population;
Humans;
Paternity;
Probability;
Tandem Repeat Sequences/genetics*
- From:
Journal of Forensic Medicine
2007;23(5):345-346
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The aim was to investigate the polymorphisms of D6S1043 and D12S391 loci among Han population and evaluate their values in paternity testing. MERTHODS: By using fluorescence dye-labeled primers and capillary electrophoresis, the allele frequencies of the two STR loci among 192 unrelated individuals were investigated.
RESULTS:Twelve alleles were observed in both D6S1043 and D12S391 loci. The ranges of allele frequencies were from 0.0026 to 0.1719 and from 0.0026 to 0.2292, respectively. The discrimination power of D6S1043 and D12S391 were 0.9656 and 0.9510. The Average exclusion probability in paternity testing for duos were 0.573 and 0.510. The Average exclusion probability in paternity testing for trios were 0.731 and 0.679, respectively. The genotypes frequencies met Hardy-Weinberg equilibrium expectation.
CONCLUSION:The results show that D6S1043 and D12S391 have high values in forensic paternity testing.
