Postmortem changes of liver phosphofructokinase-2 level in rats following different causes of death.
- Author:
Ju JIN
1
;
Bin LI
;
Bai-Guang JIAO
;
Jia FU
;
Hong HUANG
;
Yu SONG
;
Qi-Yi PENG
;
Zhi-Gang LIAO
Author Information
1. West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Asphyxia/metabolism*;
Cause of Death;
Cervical Vertebrae/injuries*;
Female;
Immunohistochemistry;
Liver/enzymology*;
Male;
Phosphofructokinase-2/metabolism*;
Postmortem Changes;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Shock, Hemorrhagic/metabolism*;
Staining and Labeling;
Time Factors
- From:
Journal of Forensic Medicine
2007;23(2):84-85
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the changes of liver phosphofructokinase-2 (PFK-2) level at different postmortem intervals as well as due to different causes of death.
METHODS:One hundred and five rats were randomly divided into 3 groups and the rats were sacrificed by either bleeding, suffocating, and neck breaking, respectively. The content of liver PFK-2 at 0, 1, 2, 4, 8, 12 and 24 hours following death were studied using immunohistochemishtry and image analysis.
RESULTS:PFK-2 content of the rat's liver in all 3 groups showed a linear decrease at different postmortem intervals with no significant statistical differences found between the different groups.
CONCLUSION:PFK-2 level in rat liver appears to decrease linearly in correlation with prolonged PMI.
