Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice.
- Author:
Wei ZHANG
1
;
Da-Wei GUAN
;
Rui ZHAO
;
Jian-Jun ZHANG
Author Information
1. Department of forensic pathology, China Medical University, Shenyang 110001, China. zhangwei6968@sina.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Apoptosis;
Calpain/metabolism*;
Disease Models, Animal;
Female;
Immunohistochemistry;
Male;
Mice;
Random Allocation;
Skin/metabolism*;
Staining and Labeling;
Time Factors;
Wound Healing;
Wounds and Injuries/physiopathology*
- From:
Journal of Forensic Medicine
2007;23(2):81-83
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expressions of calpain1 and calpain2 during the skin incised wound healing in mice.
METHODS:Expression of calpain1 and calpain2 was evaluated by immunohistochemical method.
RESULTS:Both calpain1 and calpain2 were expressed in the skin cells in the control groups. The calpain1 positive cells were remarkably increased and reached the maximal level in day 1 after skin incised wound, decreased after day 3, markedly increased again in day 5, and then gradually decreased from day 7 to 14; the calpain2 positive cells were significantly increased in day 1 and decreased to the minimum in day 3, markedly increased again in day 5, and then gradually decreased from day 7 to 10.
CONCLUSION:The changes of calpain1 and calpain2 expressions appear to be bimodal after incised wound of skin in mice.
