Morphological changes in rabbits died of potassium intoxication.
- Author:
Xin-ju ZHU
1
;
Li-ping CHEN
;
Kai LI
;
Yong-cheng XU
;
Yong KE
;
Zhen-yuan WANG
Author Information
1. Department of Forensic Medicine, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. xjzhu_js@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
Brain/pathology*;
Cadaver;
Capillaries/pathology*;
Forensic Pathology;
Injections, Intravenous/methods*;
Kidney Glomerulus/pathology*;
Male;
Myocardium/pathology*;
Phagocytosis;
Postmortem Changes;
Potassium/poisoning*;
Potassium Chloride/administration & dosage*;
Rabbits
- From:
Journal of Forensic Medicine
2007;23(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Morphologic features of the corpse of rabbits died of potassium intoxication were studied in order to elucidate an objective evidence for forensic determination of death caused by potassium intoxication.
METHODS:Macroscopic, microscopic, and ultrastructural (by transmission electron microscopy) changes were observed in the heart, brain, and kidney of rabbits killed by intravenous push or continuous infusion at 100 drips per minute with 0.3% and 1% KCl, respectively. Normal rabbits without any treatment killed by bleeding were used as controls.
RESULTS:Macroscopically, cardiac dilatation and congestion/stasis as well as ischemic and hypoxic changes in various organs were observed in rabbits died of potassium injection. Microscopically and ultrastructurally, there were destruction of the cardiac fibers with thickening, concentrating, or disappearing of the Z-line, constriction of the glomerular capillaries, enlargement of the Bowman capsule, thinning and fusion of foot processes, as well as apoptosis with phagocytosis in brain observed, particularly in the group infused with 1% KCl.
CONCLUSION:The morphologic changes observed in the heart and kidney appear to be characteristic, supporting death caused by potassium intoxication.
