Bcl-2 expression following the brain concussion in rats.
- Author:
Xu-yang ZHU
1
;
Feng WANG
;
Wei-hua FANG
;
Mao-wang WU
Author Information
1. Department of Forensic Medicine, Wannan Medical College, Wuhu 241001, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Brain/pathology*;
Brain Concussion/metabolism*;
Brain Stem/pathology*;
Cerebral Cortex/pathology*;
Contusions/pathology*;
Disease Models, Animal;
Female;
Immunohistochemistry;
Male;
Neurons/pathology*;
Proto-Oncogene Proteins c-bcl-2/metabolism*;
Rats;
Rats, Sprague-Dawley;
Time Factors
- From:
Journal of Forensic Medicine
2007;23(1):18-19
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the expression of Bcl-2 protein after brain concussion.
METHODS:Expression levels of Bel-2 protein in cortex, pontine and cerebellum of rats were investigated using immunohistochemistry.
RESULTS:There was no expression of Bcl-2 protein in control group seen. The expression of Bcl-2 protein in brain concussion groups was detected at l hour, and the expression level reached its peak 4 days after the concussion and then declined gradually.
CONCLUSION:Our findings suggest that the detection of Bel-2 protein could be an indicator for diagnosis of brain concussion and for estimation of the post injury time interval.
